Abubakr Eldirdiri






On 30 June 2017 at 1 pm Abubakr Eldirdiri from Center for Magnetic Resonance/HYPERMAG will defend his PhD thesis on Monitoring Cancer Response to Treatment with Hyperpolarized 13C MRS. Principal supervisor Professor Jan Henrik Ardenkjær-Larsen Examiners Associate Professor Axel Thielscher, DTU Elektro Senior Research Associate Mary A. McLean, Cancer Research UK, Cambridge University Associate Professor Dirk Mayer, University of Maryland Chairperson at defence Researcher Sean Bowen, DTU Elektro The defence takes place at Oersteds Plads, Building 341, auditorium 021. The defence is followed by a reception in Bulding 349, room 129 (nearby). Everyone is welcome. Popular summary Hyperpolarized Magnetic Resonance Spectroscopy (MRS) of 13C molecules has recently emerged as powerful imaging modality that can monitor response to treatment in oncology, and thereby allow selection of proper therapy fast and effectively with great benefit to patients. Conventionally, tumor response to treatment is often assessed by monitoring shrinkage of tumor size as indicated by X-ray Computed Tomography (CT) or Magnetic Resonances Imaging (MRI). However, these measurements do not give an early response in most cases. On the other hand, MRS of hyperpolarized 13C substrates provides functional information about the tumor biology that should be affected early in the treatment cycle. If the therapy is not effective, the treatment can be changed, sparing the patient unnecessary side effects and improving the prognosis. Two 13C substrates were investigated in this project; [1-13C]pyruvate, which is used to probe the metabolism, and [1,4-13C2]fumarate, which is used to detect necrosis. We showed that the conversion of hyperpolarized [1-13C]pyruvate into [1-13C]lactate can effectively indicate the response to treatment in two types of non-small-cell lung cancer, and that the performance of [1-13C]pyruvate marker is comparable to the Positron Emission Tomography marker fludeoxyglucose (FDG), which is widely used in functional imaging of cancer. We also showed that the conversion of hyperpolarized [1,4-13C2]fumarate into [1,4-13C2]malate is a useful tool to image necrosis in vivo. This finding was demonstrated in rat kidneys after ischemia/reperfusion and in rat muscles after turpentine injection. The project also aimed to improve existing 13C MRS methods to efficiently utilize the signal from hyperpolarized 13C substrates. A sequence was developed that allowed higher spatial and temporal resolutions compared to the existing method. For more information on Abubakr Eldirdiri’s research project and publications: http://www.hypermag.dtu.dk/research/phds/abubakr-eldirdiri